The Science of Sleep

Getting enough sleep is not a luxury - it is something people need for good health

Sleep is essential to every biological system and process in our bodies. Quality sleep should account for up to one third of a person's total life. Whether from an occasional bought of restlessness or a debilitating battle with chronic insomnia, the effects of lack of sleep can be severe.
Not getting enough sleep is linked with many chronic diseases and conditions - such as type 2 diabetes, heart disease, obesity, and depression - that threaten our nation's health.  (

CoFactor Medical knows how hard it can be on those suffering and those around them. That is why RestWell was developed. Not just to help people get to sleep, but to help them truly RestWell.

Check out the links below to learn more about the vital importance of getting sufficient quantity and quality of regular, healthy sleep.


Overall Health

Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures - Potter, GD, Skene DJ, Arendt J, Cade JE, Grant PJ, Hardie LJ. Endocronology Review. 2016 Dec;37(6):584-608. doi: 10.1210/er.2016-1083. Epub 2016 Oct 20. PMID: 27763782

"The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications..."

The Detrimental Effects of Inadequate Sleep on Health and Public Safety Drive an Explosion of Sleep Research - Worley, Susan L; Pharmacy & Therapeutics. 2018 Dec; 43(12):758-763. PMID: 30559589

"Sleep deprivation studies confirm the relationship between inadequate sleep and a wide range of disorders, such as hypertension, obesity and type-2 diabetes, cardiovascular disease, impaired immune functioning, and more."


Emotional Health

The Role of Sleep in Emotional Brain Function - Goldstein, Andrea; Walker, Matthew. Annual Revue of Clinical Psychology. 2014; 10:679-708. doing: 10.1146/annurev-clinpsy-032813-153716. Epub 2014 Jan 31.

"Without sleep, the ability to adequately regulate and express emotions is compromised at both a brain and behavioral level..."

Self-regulation and Social Behavior During Sleep Deprivation - Dorrian, J; Centofanti, S; Smith, A; McDermott, KD. Progress in Brain Research. 2019; 246:73-110. doing: 10.1016/bs.pbr.2019.03.010. Epub 2019 Apr 10. PMID: 31072564

"These [cognitive] changes also lead to emotional disinhibition and increased responses to negative stimuli, leading to reductions in trust, empathy, and humour." and "These behaviours are perceived and negatively responded to by others, leading to a cycle of conflict and withdrawal." 


Cognitive Ability

The Cognitive Cost of Sleep Lost - McCoy, John; Strecker, Robert; Neurobiology of Learning and Memory. 2011 Nov; 96(4):564-82. doi: 10.1016/j.nlm.2011.07.004. Epub 2011 Aug 22. PMID: 21875679; PMCID: PMC3614362

"...sleep disturbance impairs attention, executive function, emotion, learning & memory."

The Cumulative Cost of Additional Wakefulness: Dose-response Effects on Neurobehavioral Functions and Sleep Physiology from Chronic Sleep Restriction and Total Sleep Deprivation - Van Dongen HP, Maislin G, Mullington JM, Dinges DF.  Sleep. 2003 Mar 15:26(2):117-26. doi: 10.1093/sleep/26.2.117. Erratum in: Sleep. 2004 Jun 15; 27(4):600. PMID:12683469.

"It appears that even relatively moderate sleep restriction can seriouslyl impair waking neurobehavioral functions in health adults." 

Cognitive Benefits of Sleep and their Loss Due to Sleep Deprivation - Ellenbogen, Jeffrey M; Neurology. 2005 apr 12;64(7):E25-7. doi:10.1212/01wnl.0000164850.68115.81. PMID:15824327

"The detriments resulting from sleep loss include impaired cognitive and behavioral performance..." and "...missing sleep-dependent cognitive processing such as memory consolidation and insight formation."


Weight Gain

Sleep Patterns, Diet Quality and Energy Balance - Chaput, Jean-Philippe. Physiology & Behavior. 2014 Jul;134:86-91. doing: 10.1016/j.physbeh.2013.09.006. Epub 2013 Sep 17. PMID: 24051052.

"In summary, multiple connections exist between sleep patterns, eating behavior and energy balance."

Sleep Debt and Obesity - Bayon, Virginie, et al. Annals of Medicine. 2014 Aug;46(5):264-72. doing. 10.3109/07853890.2014.931103. Epub 2014 Jull 11. PMID: 25012962.

"Short sleep duration has been shown to be associated with elevated body mass index (BMI) in many epidemiological studies."

Short Sleep Duration and Weight Gain: A Systematic Review - Patel, Sanjay R; Obesity (Silver Spring). 2008, Mar 16(3):643-53. doi: 10.1038/oby.2007.118. Epub 2008, Jan 17. PMID: 18239586; PMCID: PMC2723045

"Short sleep duration appears independently associated with weight gain, particularly in younger age groups."

Physical Performance

Sleep Hygiene for Optimizing Recovery in Athletes: Review and Recommendations - Vitale, KC; Owens, R; Hopkins, SR; Malhotra, A. International Journal for Sports Medicine. 2019; 40(08): 535-543. doi. 10.1055/a-0905-3103

"For sports medicine providers, the negative effects of sleep deprivation cannot be overstated to athletes."

Optimizing Sleep to Maximize Performance: Implications and Recommendations for Elite Athletes - Simpson NS, Gibbs EL, Matheson GO. Scan Journal of Medical Sports Science. 2017 Mar; 27(3):266-274. doing: 10.1111/sms.12703.Epub 2016 Jul 1. PMID: 27367265



*Neither these statements nor RestWell products have been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.